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Unknown  |  1992-06-06  |  400.0 KB

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66% dexvert OS/2 Installation Package (archive/os2InstallPackage) ext Supported
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1% dexvert Newton Package (archive/newtonPackage) ext Unsupported
1% dexvert Independence War 2 mod Package (other/independenceWar2ModPackage) ext Unsupported
100% file data default



hex view
+--------+-------------------------+-------------------------+--------+--------+
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|000027b0| 43 68 61 70 74 65 72 20 | 36 20 2d 2d 20 49 6e 66 |Chapter |6 -- Inf|
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|000027d0| 20 61 6e 64 20 44 65 76 | 65 6c 6f 70 6d 65 6e 74 | and Dev|elopment|
|000027e0| 61 6c 20 49 6d 6d 75 6e | 6f 6c 6f 67 79 0d 0a 0d |al Immun|ology...|
|000027f0| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
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|00002820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002840| 0a 41 73 73 6f 63 69 61 | 74 69 6f 6e 20 6f 66 20 |.Associa|tion of |
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|00003760| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004390| 0a 24 44 61 74 65 7b 4a | 75 6e 65 20 31 39 38 39 |.$Date{J|une 1989|
|000043a0| 7d 0d 0a 24 59 42 56 6f | 6c 7b 31 39 39 30 20 59 |}..$YBVo|l{1990 Y|
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|000043c0| 61 74 61 6c 20 61 6e 64 | 20 50 65 72 69 6e 61 74 |atal and| Perinat|
|000043d0| 61 6c 20 4d 65 64 69 63 | 69 6e 65 7d 0d 0a 24 43 |al Medic|ine}..$C|
|000043e0| 68 61 70 74 65 72 7b 36 | 2d 32 30 7d 0d 0a 24 59 |hapter{6|-20}..$Y|
|000043f0| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 4b 6c 61 |BEditor{|Drs. Kla|
|00004400| 75 73 20 61 6e 64 20 46 | 61 6e 61 72 6f 66 66 7d |us and F|anaroff}|
|00004410| 0d 0a 24 54 61 62 6c 65 | 7b 54 61 62 6c 65 20 4f |..$Table|{Table O|
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|00004430| 74 61 74 6f 72 7b 41 2e | 41 2e 20 46 61 6e 61 72 |tator{A.|A. Fanar|
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|00004450| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 43 29 |...Copyr|ight (C)|
|00004460| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00004470| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00004480| 6e 63 2e 20 31 39 39 31 | 0d 0a 0d 0a 31 39 39 30 |nc. 1991|....1990|
|00004490| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 4e 65 | Year Bo|ok of Ne|
|000044a0| 6f 6e 61 74 61 6c 20 61 | 6e 64 20 50 65 72 69 6e |onatal a|nd Perin|
|000044b0| 61 74 61 6c 20 4d 65 64 | 69 63 69 6e 65 0d 0a 0d |atal Med|icine...|
|000044c0| 0a 43 68 61 70 74 65 72 | 20 36 20 2d 2d 20 49 6e |.Chapter| 6 -- In|
|000044d0| 66 65 63 74 69 6f 75 73 | 20 44 69 73 65 61 73 65 |fectious| Disease|
|000044e0| 73 20 61 6e 64 20 44 65 | 76 65 6c 6f 70 6d 65 6e |s and De|velopmen|
|000044f0| 74 61 6c 20 49 6d 6d 75 | 6e 6f 6c 6f 67 79 0d 0a |tal Immu|nology..|
|00004500| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00004510| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004530| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004540| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004550| 0d 0a 45 66 66 65 63 74 | 20 6f 66 20 49 6d 6d 75 |..Effect| of Immu|
|00004560| 6e 65 20 47 6c 6f 62 75 | 6c 69 6e 20 49 6e 74 72 |ne Globu|lin Intr|
|00004570| 61 76 65 6e 6f 75 73 20 | 6f 6e 20 4f 70 73 6f 6e |avenous |on Opson|
|00004580| 69 7a 61 74 69 6f 6e 20 | 6f 66 20 42 61 63 74 65 |ization |of Bacte|
|00004590| 72 69 61 20 62 79 20 43 | 6c 61 73 73 69 63 0d 0a |ria by C|lassic..|
|000045a0| 61 6e 64 20 41 6c 74 65 | 72 6e 61 74 69 76 65 20 |and Alte|rnative |
|000045b0| 43 6f 6d 70 6c 65 6d 65 | 6e 74 20 50 61 74 68 77 |Compleme|nt Pathw|
|000045c0| 61 79 73 20 69 6e 20 50 | 72 65 6d 61 74 75 72 65 |ays in P|remature|
|000045d0| 20 53 65 72 75 6d 0d 0a | 0d 0a 53 68 61 69 6f 20 | Serum..|..Shaio |
|000045e0| 4d 2d 46 3b 20 59 61 6e | 67 20 4b 44 3b 20 42 6f |M-F; Yan|g KD; Bo|
|000045f0| 68 6e 73 61 63 6b 20 4a | 46 3b 20 48 69 6c 6c 20 |hnsack J|F; Hill |
|00004600| 48 52 0d 0a 28 4e 61 74 | 6c 20 44 65 66 65 6e 73 |HR..(Nat|l Defens|
|00004610| 65 20 4d 65 64 20 43 74 | 72 2c 20 54 61 69 70 65 |e Med Ct|r, Taipe|
|00004620| 69 2c 20 54 61 69 77 61 | 6e 3b 20 55 6e 69 76 20 |i, Taiwa|n; Univ |
|00004630| 6f 66 20 55 74 61 68 29 | 0d 0a 50 65 64 69 61 74 |of Utah)|..Pediat|
|00004640| 72 20 52 65 73 20 32 35 | 3a 36 33 34 2d 36 34 30 |r Res 25|:634-640|
|00004650| 2c 20 4a 75 6e 65 20 31 | 39 38 39 0d 0a 2d 2d 2d |, June 1|989..---|
|00004660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004670| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004680| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004690| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000046a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
|000046b0| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|... |
|000046c0| 44 65 66 65 63 74 69 76 | 65 20 6f 70 73 6f 6e 6f |Defectiv|e opsono|
|000046d0| 70 68 61 67 6f 63 79 74 | 6f 73 69 73 20 69 6e 20 |phagocyt|osis in |
|000046e0| 70 72 65 6d 61 74 75 72 | 65 20 6e 65 6f 6e 61 74 |prematur|e neonat|
|000046f0| 65 73 20 69 73 20 63 61 | 75 73 65 64 20 62 79 20 |es is ca|used by |
|00004700| 74 68 65 20 6c 61 63 6b | 0d 0a 6f 66 20 65 66 66 |the lack|..of eff|
|00004710| 65 63 74 69 76 65 20 61 | 6e 74 69 62 6f 64 69 65 |ective a|ntibodie|
|00004720| 73 20 61 6e 64 20 6c 6f | 77 20 63 6f 6d 70 6c 65 |s and lo|w comple|
|00004730| 6d 65 6e 74 20 61 63 74 | 69 76 69 74 79 2e 20 20 |ment act|ivity. |
|00004740| 49 6d 6d 75 6e 65 20 67 | 6c 6f 62 75 6c 69 6e 0d |Immune g|lobulin.|
|00004750| 0a 61 64 6d 69 6e 69 73 | 74 65 72 65 64 20 69 6e |.adminis|tered in|
|00004760| 74 72 61 76 65 6e 6f 75 | 73 6c 79 20 28 49 47 49 |travenou|sly (IGI|
|00004770| 56 29 20 6d 61 79 20 62 | 65 20 62 65 6e 65 66 69 |V) may b|e benefi|
|00004780| 63 69 61 6c 20 69 6e 20 | 70 72 65 76 65 6e 74 69 |cial in |preventi|
|00004790| 6e 67 20 6f 72 20 74 72 | 65 61 74 69 6e 67 0d 0a |ng or tr|eating..|
|000047a0| 73 65 70 73 69 73 20 69 | 6e 20 70 72 65 6d 61 74 |sepsis i|n premat|
|000047b0| 75 72 65 20 61 6e 64 20 | 6c 6f 77 2d 62 69 72 74 |ure and |low-birt|
|000047c0| 68 2d 77 65 69 67 68 74 | 20 6e 65 6f 6e 61 74 65 |h-weight| neonate|
|000047d0| 73 2e 20 20 54 68 65 20 | 65 66 66 65 63 74 73 20 |s. The |effects |
|000047e0| 6f 66 20 49 47 49 56 20 | 6f 6e 20 74 68 65 0d 0a |of IGIV |on the..|
|000047f0| 6f 70 73 6f 6e 6f 70 68 | 61 67 6f 63 79 74 6f 73 |opsonoph|agocytos|
|00004800| 69 73 20 6f 66 20 62 61 | 63 74 65 72 69 61 20 62 |is of ba|cteria b|
|00004810| 79 20 62 6f 74 68 20 63 | 6f 6d 70 6c 65 6d 65 6e |y both c|omplemen|
|00004820| 74 20 70 61 74 68 77 61 | 79 73 20 69 6e 20 76 65 |t pathwa|ys in ve|
|00004830| 6e 6f 75 73 20 62 6c 6f | 6f 64 0d 0a 73 61 6d 70 |nous blo|od..samp|
|00004840| 6c 65 73 20 66 72 6f 6d | 20 61 64 75 6c 74 73 20 |les from| adults |
|00004850| 61 6e 64 20 70 72 65 6d | 61 74 75 72 65 20 69 6e |and prem|ature in|
|00004860| 66 61 6e 74 73 20 77 61 | 73 20 61 73 73 65 73 73 |fants wa|s assess|
|00004870| 65 64 2e 20 20 54 68 65 | 20 62 61 63 74 65 72 69 |ed. The| bacteri|
|00004880| 61 20 75 73 65 64 0d 0a | 77 65 72 65 20 74 68 65 |a used..|were the|
|00004890| 20 6e 6f 6e 65 6e 63 61 | 70 73 75 6c 61 74 65 64 | nonenca|psulated|
|000048a0| 20 53 74 61 70 68 79 6c | 6f 63 6f 63 63 75 73 20 | Staphyl|ococcus |
|000048b0| 61 75 72 65 75 73 20 61 | 6e 64 20 53 61 6c 6d 6f |aureus a|nd Salmo|
|000048c0| 6e 65 6c 6c 61 20 65 6e | 74 65 72 69 74 69 64 69 |nella en|teritidi|
|000048d0| 73 2c 20 61 6e 64 0d 0a | 74 68 65 20 65 6e 63 61 |s, and..|the enca|
|000048e0| 70 73 75 6c 61 74 65 64 | 20 53 74 72 65 70 74 6f |psulated| Strepto|
|000048f0| 63 6f 63 63 75 73 20 70 | 79 6f 67 65 6e 65 73 20 |coccus p|yogenes |
|00004900| 61 6e 64 20 45 73 63 68 | 65 72 69 63 68 69 61 20 |and Esch|erichia |
|00004910| 63 6f 6c 69 2e 0d 0a 20 | 20 20 20 20 49 6e 64 69 |coli... | Indi|
|00004920| 72 65 63 74 20 69 6d 6d | 75 6e 6f 66 6c 75 6f 72 |rect imm|unofluor|
|00004930| 65 73 63 65 6e 63 65 20 | 64 65 6d 6f 6e 73 74 72 |escence |demonstr|
|00004940| 61 74 65 64 20 74 68 61 | 74 20 49 47 49 56 20 68 |ated tha|t IGIV h|
|00004950| 61 64 20 73 70 65 63 69 | 66 69 63 20 61 6e 74 69 |ad speci|fic anti|
|00004960| 62 6f 64 79 0d 0a 74 69 | 74 65 72 73 20 6f 66 20 |body..ti|ters of |
|00004970| 31 3a 33 32 20 66 6f 72 | 20 53 74 61 2e 20 61 75 |1:32 for| Sta. au|
|00004980| 72 65 75 73 20 61 6e 64 | 20 53 61 6c 2e 20 65 6e |reus and| Sal. en|
|00004990| 74 65 72 69 74 69 64 69 | 73 2c 20 61 6e 64 20 31 |teritidi|s, and 1|
|000049a0| 3a 38 20 66 6f 72 20 53 | 74 72 2e 20 70 79 6f 67 |:8 for S|tr. pyog|
|000049b0| 65 6e 65 73 0d 0a 61 6e | 64 20 45 2e 20 63 6f 6c |enes..an|d E. col|
|000049c0| 69 2e 20 20 49 6e 74 72 | 61 76 65 6e 6f 75 73 20 |i. Intr|avenous |
|000049d0| 69 6d 6d 75 6e 65 20 67 | 6c 6f 62 75 6c 69 6e 20 |immune g|lobulin |
|000049e0| 61 6c 6f 6e 65 20 68 61 | 64 20 6e 6f 20 64 69 72 |alone ha|d no dir|
|000049f0| 65 63 74 20 6f 70 73 6f | 6e 69 63 20 61 63 74 69 |ect opso|nic acti|
|00004a00| 76 69 74 79 0d 0a 61 67 | 61 69 6e 73 74 20 74 68 |vity..ag|ainst th|
|00004a10| 65 73 65 20 6f 72 67 61 | 6e 69 73 6d 73 2e 20 20 |ese orga|nisms. |
|00004a20| 41 64 64 69 74 69 6f 6e | 20 6f 66 20 49 47 49 56 |Addition| of IGIV|
|00004a30| 20 74 6f 20 73 65 72 75 | 6d 20 66 72 6f 6d 20 6e | to seru|m from n|
|00004a40| 6f 72 6d 61 6c 20 61 64 | 75 6c 74 73 20 64 69 64 |ormal ad|ults did|
|00004a50| 20 6e 6f 74 0d 0a 61 66 | 66 65 63 74 20 6f 70 73 | not..af|fect ops|
|00004a60| 6f 6e 69 63 20 61 63 74 | 69 76 69 74 79 20 61 67 |onic act|ivity ag|
|00004a70| 61 69 6e 73 74 20 74 68 | 65 73 65 20 6f 72 67 61 |ainst th|ese orga|
|00004a80| 6e 69 73 6d 73 2e 20 20 | 48 6f 77 65 76 65 72 2c |nisms. |However,|
|00004a90| 20 61 64 64 69 74 69 6f | 6e 20 6f 66 20 49 47 49 | additio|n of IGI|
|00004aa0| 56 20 74 6f 0d 0a 73 65 | 72 75 6d 20 66 72 6f 6d |V to..se|rum from|
|00004ab0| 20 70 72 65 6d 61 74 75 | 72 65 20 69 6e 66 61 6e | prematu|re infan|
|00004ac0| 74 73 20 73 69 67 6e 69 | 66 69 63 61 6e 74 6c 79 |ts signi|ficantly|
|00004ad0| 20 69 6d 70 72 6f 76 65 | 64 20 6f 70 73 6f 6e 69 | improve|d opsoni|
|00004ae0| 63 20 61 63 74 69 76 69 | 74 79 20 62 79 20 62 6f |c activi|ty by bo|
|00004af0| 74 68 0d 0a 74 68 65 20 | 63 6c 61 73 73 69 63 20 |th..the |classic |
|00004b00| 61 6e 64 20 61 6c 74 65 | 72 6e 61 74 69 76 65 20 |and alte|rnative |
|00004b10| 63 6f 6d 70 6c 65 6d 65 | 6e 74 20 70 61 74 68 77 |compleme|nt pathw|
|00004b20| 61 79 73 20 61 67 61 69 | 6e 73 74 20 74 68 65 20 |ays agai|nst the |
|00004b30| 6e 6f 6e 65 6e 63 61 70 | 73 75 6c 61 74 65 64 0d |nonencap|sulated.|
|00004b40| 0a 6f 72 67 61 6e 69 73 | 6d 73 20 74 6f 20 6c 65 |.organis|ms to le|
|00004b50| 76 65 6c 73 20 6d 61 74 | 63 68 69 6e 67 20 74 68 |vels mat|ching th|
|00004b60| 6f 73 65 20 69 6e 20 6e | 6f 72 6d 61 6c 20 61 64 |ose in n|ormal ad|
|00004b70| 75 6c 74 20 73 65 72 75 | 6d 20 28 74 61 62 6c 65 |ult seru|m (table|
|00004b80| 29 20 61 6e 64 20 6d 61 | 72 6b 65 64 6c 79 0d 0a |) and ma|rkedly..|
|00004b90| 69 6e 63 72 65 61 73 65 | 64 20 43 33 20 64 65 70 |increase|d C3 dep|
|00004ba0| 6f 73 69 74 69 6f 6e 20 | 6f 6e 20 62 61 63 74 65 |osition |on bacte|
|00004bb0| 72 69 61 20 62 79 20 62 | 6f 74 68 20 63 6f 6d 70 |ria by b|oth comp|
|00004bc0| 6c 65 6d 65 6e 74 20 70 | 61 74 68 77 61 79 73 20 |lement p|athways |
|00004bd0| 28 46 69 67 20 36 2d 34 | 29 2e 0d 0a 20 20 20 20 |(Fig 6-4|)... |
|00004be0| 20 53 75 70 70 6c 65 6d | 65 6e 74 61 74 69 6f 6e | Supplem|entation|
|00004bf0| 20 6f 66 20 70 72 65 6d | 61 74 75 72 65 20 73 65 | of prem|ature se|
|00004c00| 72 75 6d 20 77 69 74 68 | 20 61 6e 20 49 47 49 56 |rum with| an IGIV|
|00004c10| 20 70 72 65 70 61 72 61 | 74 69 6f 6e 20 63 6f 6e | prepara|tion con|
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|00004c30| 74 65 72 73 20 6f 66 20 | 73 70 65 63 69 66 69 63 |ters of |specific|
|00004c40| 20 61 6e 74 69 62 6f 64 | 79 20 61 70 70 65 61 72 | antibod|y appear|
|00004c50| 73 20 74 6f 20 65 6e 68 | 61 6e 63 65 20 6f 70 73 |s to enh|ance ops|
|00004c60| 6f 6e 6f 70 68 61 67 6f | 63 79 74 6f 73 69 73 20 |onophago|cytosis |
|00004c70| 6f 66 0d 0a 62 61 63 74 | 65 72 69 61 20 62 79 20 |of..bact|eria by |
|00004c80| 65 6e 68 61 6e 63 69 6e | 67 20 63 6f 6d 70 6c 65 |enhancin|g comple|
|00004c90| 6d 65 6e 74 20 70 61 74 | 68 77 61 79 20 61 63 74 |ment pat|hway act|
|00004ca0| 69 76 61 74 69 6f 6e 2c | 20 70 61 72 74 69 63 75 |ivation,| particu|
|00004cb0| 6c 61 72 6c 79 20 74 68 | 65 0d 0a 61 6c 74 65 72 |larly th|e..alter|
|00004cc0| 6e 61 74 69 76 65 20 70 | 61 74 68 77 61 79 2e 20 |native p|athway. |
|00004cd0| 20 54 68 69 73 20 66 69 | 6e 64 69 6e 67 20 68 61 | This fi|nding ha|
|00004ce0| 73 20 63 6c 69 6e 69 63 | 61 6c 20 69 6d 70 6c 69 |s clinic|al impli|
|00004cf0| 63 61 74 69 6f 6e 73 20 | 66 6f 72 20 74 68 65 0d |cations |for the.|
|00004d00| 0a 64 65 76 65 6c 6f 70 | 6d 65 6e 74 20 6f 66 20 |.develop|ment of |
|00004d10| 74 68 65 72 61 70 65 75 | 74 69 63 20 72 65 67 69 |therapeu|tic regi|
|00004d20| 6d 65 6e 73 20 61 69 6d | 65 64 20 61 74 20 74 68 |mens aim|ed at th|
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|00004d40| 20 70 72 6f 70 68 79 6c | 61 78 69 73 20 6f 66 0d | prophyl|axis of.|
|00004d50| 0a 73 65 70 73 69 73 20 | 69 6e 20 70 72 65 6d 61 |.sepsis |in prema|
|00004d60| 74 75 72 65 20 69 6e 66 | 61 6e 74 73 2e 0d 0a 0d |ture inf|ants....|
|00004d70| 0a 50 6f 73 74 2d 43 6f | 6d 6d 65 6e 74 0d 0a 0d |.Post-Co|mment...|
|00004d80| 0a 20 20 20 20 20 22 41 | 20 64 65 73 70 65 72 61 |. "A| despera|
|00004d90| 74 65 20 64 69 73 65 61 | 73 65 20 72 65 71 75 69 |te disea|se requi|
|00004da0| 72 65 73 20 61 20 64 61 | 6e 67 65 72 6f 75 73 20 |res a da|ngerous |
|00004db0| 72 65 6d 65 64 79 2e 22 | 2d 2d 47 75 79 20 46 61 |remedy."|--Guy Fa|
|00004dc0| 77 6b 65 73 2e 0d 0a 20 | 20 20 20 20 4e 6f 73 6f |wkes... | Noso|
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|00004e30| 41 20 6e 75 6d 62 65 72 | 20 6f 66 20 69 6e 74 72 |A number| of intr|
|00004e40| 61 76 65 6e 6f 75 73 20 | 69 6d 6d 75 6e 6f 67 6c |avenous |immunogl|
|00004e50| 6f 62 75 6c 69 6e 20 28 | 49 56 49 47 29 0d 0a 70 |obulin (|IVIG)..p|
|00004e60| 72 65 70 61 72 61 74 69 | 6f 6e 73 20 68 61 76 65 |reparati|ons have|
|00004e70| 20 62 65 65 6e 20 65 76 | 61 6c 75 61 74 65 64 20 | been ev|aluated |
|00004e80| 66 6f 72 20 74 68 65 20 | 70 72 65 76 65 6e 74 69 |for the |preventi|
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|00004ea0| 6f 66 20 6e 65 6f 6e 61 | 74 61 6c 0d 0a 69 6e 66 |of neona|tal..inf|
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|00004ec0| 6c 20 72 65 70 6f 72 74 | 73 20 68 61 76 65 20 62 |l report|s have b|
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|00004ee0| 20 61 6c 74 68 6f 75 67 | 68 20 73 61 6d 70 6c 65 | althoug|h sample|
|00004ef0| 20 73 69 7a 65 20 68 61 | 73 0d 0a 62 65 65 6e 20 | size ha|s..been |
|00004f00| 74 6f 6f 20 73 6d 61 6c | 6c 20 74 6f 20 61 72 72 |too smal|l to arr|
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|00004f30| 54 68 69 73 20 65 6c 65 | 67 61 6e 74 20 73 74 75 |This ele|gant stu|
|00004f40| 64 79 0d 0a 66 75 72 74 | 68 65 72 20 73 75 70 70 |dy..furt|her supp|
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|00004f60| 6c 65 20 66 6f 72 20 69 | 6d 6d 75 6e 6f 67 6c 6f |le for i|mmunoglo|
|00004f70| 62 75 6c 69 6e 20 69 6e | 66 75 73 69 6f 6e 20 62 |bulin in|fusion b|
|00004f80| 79 20 64 65 6d 6f 6e 73 | 74 72 61 74 69 6e 67 0d |y demons|trating.|
|00004f90| 0a 75 6e 65 71 75 69 76 | 6f 63 61 6c 6c 79 20 74 |.unequiv|ocally t|
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|00004fd0| 20 65 6e 68 61 6e 63 65 | 73 0d 0a 6f 70 73 6f 6e | enhance|s..opson|
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|00004ff0| 20 62 61 63 74 65 72 69 | 61 2e 20 20 46 75 72 74 | bacteri|a. Furt|
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|00005030| 6f 6d 70 6c 65 6d 65 6e | 74 20 70 61 74 68 77 61 |omplemen|t pathwa|
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|00005050| 68 65 20 61 6c 74 65 72 | 6e 61 74 69 76 65 20 70 |he alter|native p|
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|00005070| 47 0d 0a 65 6e 68 61 6e | 63 65 64 20 74 68 65 20 |G..enhan|ced the |
|00005080| 6f 70 73 6f 6e 69 63 20 | 61 63 74 69 76 69 74 79 |opsonic |activity|
|00005090| 20 61 67 61 69 6e 73 74 | 20 74 68 65 20 6e 6f 6e | against| the non|
|000050a0| 65 6e 63 61 70 73 75 6c | 61 74 65 64 20 62 61 63 |encapsul|ated bac|
|000050b0| 74 65 72 69 61 20 69 6e | 20 74 68 65 0d 0a 70 72 |teria in| the..pr|
|000050c0| 65 73 65 6e 63 65 20 6f | 66 20 63 6f 6d 70 6c 65 |esence o|f comple|
|000050d0| 6d 65 6e 74 2c 20 62 75 | 74 20 6e 6f 74 20 74 68 |ment, bu|t not th|
|000050e0| 61 74 20 66 6f 72 20 74 | 68 65 20 65 6e 63 61 70 |at for t|he encap|
|000050f0| 73 75 6c 61 74 65 64 20 | 62 61 63 74 65 72 69 61 |sulated |bacteria|
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|00005580| 6c 69 61 74 69 6f 6e 7b | 55 6e 69 76 20 6f 66 20 |liation{|Univ of |
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|00005610| 24 44 61 74 65 7b 46 65 | 62 72 75 61 72 79 20 31 |$Date{Fe|bruary 1|
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|00005660| 0a 24 43 68 61 70 74 65 | 72 7b 37 2d 31 7d 0d 0a |.$Chapte|r{7-1}..|
|00005670| 24 59 42 45 64 69 74 6f | 72 7b 44 72 73 2e 20 4b |$YBEdito|r{Drs. K|
|00005680| 6c 61 75 73 20 61 6e 64 | 20 46 61 6e 61 72 6f 66 |laus and| Fanarof|
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|000056a0| 6f 6d 6d 65 6e 74 61 74 | 6f 72 7b 41 2e 41 2e 20 |ommentat|or{A.A. |
|000056b0| 46 61 6e 61 72 6f 66 66 | 2c 20 4d 2e 42 2e 42 2e |Fanaroff|, M.B.B.|
|000056c0| 43 68 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |Ch.}....|Copyrigh|
|000056d0| 74 20 28 43 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (C) Ye|ar Book |
|000056e0| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|000056f0| 72 73 2c 20 49 6e 63 2e | 20 31 39 39 31 0d 0a 0d |rs, Inc.| 1991...|
|00005700| 0a 31 39 39 30 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1990 Ye|ar Book |
|00005710| 6f 66 20 4e 65 6f 6e 61 | 74 61 6c 20 61 6e 64 20 |of Neona|tal and |
|00005720| 50 65 72 69 6e 61 74 61 | 6c 20 4d 65 64 69 63 69 |Perinata|l Medici|
|00005730| 6e 65 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 37 20 |ne....Ch|apter 7 |
|00005740| 2d 2d 20 54 68 65 20 4e | 65 72 76 6f 75 73 20 53 |-- The N|ervous S|
|00005750| 79 73 74 65 6d 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |ystem...|.-------|
|00005760| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005770| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005780| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005790| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057a0| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 50 6f 73 74 75 72 65 |-------.|.Posture|
|000057b0| 20 61 6e 64 20 53 70 6f | 6e 74 61 6e 65 6f 75 73 | and Spo|ntaneous|
|000057c0| 20 4d 6f 74 69 6c 69 74 | 79 20 69 6e 20 46 75 6c | Motilit|y in Ful|
|000057d0| 6c 74 65 72 6d 20 49 6e | 66 61 6e 74 73 0d 0a 0d |lterm In|fants...|
|000057e0| 0a 43 69 6f 6e 69 20 47 | 3b 20 46 65 72 72 61 72 |.Cioni G|; Ferrar|
|000057f0| 69 20 46 3b 20 50 72 65 | 63 68 74 6c 20 48 46 52 |i F; Pre|chtl HFR|
|00005800| 0d 0a 28 55 6e 69 76 20 | 6f 66 20 50 69 73 61 2c |..(Univ |of Pisa,|
|00005810| 20 49 74 61 6c 79 3b 20 | 55 6e 69 76 20 6f 66 20 | Italy; |Univ of |
|00005820| 4d 6f 64 65 6e 61 2c 20 | 49 74 61 6c 79 3b 20 55 |Modena, |Italy; U|
|00005830| 6e 69 76 20 6f 66 20 47 | 72 6f 6e 69 6e 67 65 6e |niv of G|roningen|
|00005840| 2c 20 54 68 65 0d 0a 4e | 65 74 68 65 72 6c 61 6e |, The..N|etherlan|
|00005850| 64 73 29 0d 0a 45 61 72 | 6c 79 20 48 75 6d 20 44 |ds)..Ear|ly Hum D|
|00005860| 65 76 20 31 38 3a 32 34 | 37 2d 32 36 32 2c 20 46 |ev 18:24|7-262, F|
|00005870| 65 62 72 75 61 72 79 20 | 31 39 38 39 0d 0a 2d 2d |ebruary |1989..--|
|00005880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000058a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000058b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000058c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|000058d0| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|000058e0| 20 4d 6f 76 65 6d 65 6e | 74 20 70 61 74 74 65 72 | Movemen|t patter|
|000058f0| 6e 73 20 61 6e 64 20 6d | 6f 74 69 6c 69 74 79 20 |ns and m|otility |
|00005900| 69 6e 20 66 65 74 75 73 | 65 73 20 61 6e 64 20 70 |in fetus|es and p|
|00005910| 72 65 74 65 72 6d 20 69 | 6e 66 61 6e 74 73 20 68 |reterm i|nfants h|
|00005920| 61 76 65 20 62 65 65 6e | 0d 0a 65 78 61 6d 69 6e |ave been|..examin|
|00005930| 65 64 2c 20 62 75 74 20 | 66 65 77 20 64 61 74 61 |ed, but |few data|
|00005940| 20 61 72 65 20 61 76 61 | 69 6c 61 62 6c 65 20 66 | are ava|ilable f|
|00005950| 6f 72 20 68 65 61 6c 74 | 68 79 20 66 75 6c 6c 2d |or healt|hy full-|
|00005960| 74 65 72 6d 20 69 6e 66 | 61 6e 74 73 2e 20 20 50 |term inf|ants. P|
|00005970| 6f 73 74 75 72 65 73 0d | 0a 61 6e 64 20 6d 6f 74 |ostures.|.and mot|
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|000059a0| 72 6d 20 69 6e 66 61 6e | 74 73 20 77 65 72 65 20 |rm infan|ts were |
|000059b0| 6f 62 73 65 72 76 65 64 | 20 64 69 72 65 63 74 6c |observed| directl|
|000059c0| 79 20 6f 72 0d 0a 76 69 | 64 65 6f 72 65 63 6f 72 |y or..vi|deorecor|
|000059d0| 64 65 64 20 64 75 72 69 | 6e 67 20 74 68 65 20 66 |ded duri|ng the f|
|000059e0| 69 72 73 74 20 66 65 77 | 20 64 61 79 73 20 6f 66 |irst few| days of|
|000059f0| 20 6c 69 66 65 2e 20 20 | 42 65 68 61 76 69 6f 72 | life. |Behavior|
|00005a00| 61 6c 20 73 74 61 74 65 | 73 20 77 65 72 65 0d 0a |al state|s were..|
|00005a10| 61 73 73 65 73 73 65 64 | 20 66 72 6f 6d 20 62 6f |assessed| from bo|
|00005a20| 64 79 20 6d 6f 76 65 6d | 65 6e 74 73 2c 20 6f 70 |dy movem|ents, op|
|00005a30| 65 6e 69 6e 67 20 6f 72 | 20 63 6c 6f 73 69 6e 67 |ening or| closing|
|00005a40| 20 6f 66 20 65 79 65 73 | 2c 20 63 72 79 69 6e 67 | of eyes|, crying|
|00005a50| 2c 20 61 6e 64 0d 0a 72 | 65 73 70 69 72 61 74 69 |, and..r|espirati|
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|00005a70| 61 6c 20 72 65 70 65 72 | 74 6f 69 72 65 20 68 61 |al reper|toire ha|
|00005a80| 64 20 67 72 65 61 74 20 | 76 61 72 69 61 62 69 6c |d great |variabil|
|00005a90| 69 74 79 20 62 6f 74 68 | 20 77 69 74 68 69 6e 20 |ity both| within |
|00005aa0| 61 6e 64 20 62 65 74 77 | 65 65 6e 0d 0a 69 6e 66 |and betw|een..inf|
|00005ab0| 61 6e 74 73 2e 20 20 4e | 6f 20 73 70 65 63 69 61 |ants. N|o specia|
|00005ac0| 6c 20 70 6f 73 74 75 72 | 65 20 77 61 73 20 63 68 |l postur|e was ch|
|00005ad0| 61 72 61 63 74 65 72 69 | 73 74 69 63 20 6f 66 20 |aracteri|stic of |
|00005ae0| 61 6e 79 20 62 65 68 61 | 76 69 6f 72 61 6c 20 73 |any beha|vioral s|
|00005af0| 74 61 74 65 2e 20 20 54 | 68 65 0d 0a 70 72 65 76 |tate. T|he..prev|
|00005b00| 69 6f 75 73 6c 79 20 72 | 65 70 6f 72 74 65 64 20 |iously r|eported |
|00005b10| 70 72 65 66 65 72 65 6e | 63 65 20 66 6f 72 20 66 |preferen|ce for f|
|00005b20| 6c 65 78 69 6f 6e 20 6f | 66 20 6c 65 67 73 20 61 |lexion o|f legs a|
|00005b30| 6e 64 20 68 65 61 64 20 | 74 6f 20 74 68 65 20 72 |nd head |to the r|
|00005b40| 69 67 68 74 20 77 61 73 | 0d 0a 6e 6f 74 20 6f 62 |ight was|..not ob|
|00005b50| 73 65 72 76 65 64 2e 20 | 20 49 6e 66 61 6e 74 73 |served. | Infants|
|00005b60| 20 72 61 72 65 6c 79 20 | 61 73 73 75 6d 65 64 20 | rarely |assumed |
|00005b70| 74 68 65 20 73 61 6d 65 | 20 70 6f 73 74 75 72 65 |the same| posture|
|00005b80| 73 20 6f 6e 20 74 68 65 | 20 66 6f 75 72 74 68 20 |s on the| fourth |
|00005b90| 64 61 79 20 74 68 61 74 | 0d 0a 74 68 65 79 20 68 |day that|..they h|
|00005ba0| 61 64 20 6f 6e 20 74 68 | 65 20 66 69 72 73 74 20 |ad on th|e first |
|00005bb0| 64 61 79 2e 20 20 45 78 | 74 65 6e 64 65 64 20 70 |day. Ex|tended p|
|00005bc0| 6f 73 74 75 72 65 73 20 | 77 65 72 65 20 6d 6f 72 |ostures |were mor|
|00005bd0| 65 20 63 6f 6d 6d 6f 6e | 20 6f 6e 20 64 61 79 20 |e common| on day |
|00005be0| 34 2e 0d 0a 52 61 74 65 | 73 20 6f 66 20 6d 6f 74 |4...Rate|s of mot|
|00005bf0| 6f 72 20 61 63 74 69 76 | 69 74 79 20 64 69 64 20 |or activ|ity did |
|00005c00| 6e 6f 74 20 64 69 66 66 | 65 72 20 61 63 63 6f 72 |not diff|er accor|
|00005c10| 64 69 6e 67 20 74 6f 20 | 74 68 65 20 64 61 79 2e |ding to |the day.|
|00005c20| 20 20 52 61 74 65 20 64 | 69 66 66 65 72 65 6e 63 | Rate d|ifferenc|
|00005c30| 65 73 0d 0a 62 65 74 77 | 65 65 6e 20 69 6e 66 61 |es..betw|een infa|
|00005c40| 6e 74 73 20 77 65 72 65 | 20 67 72 65 61 74 2c 20 |nts were| great, |
|00005c50| 62 75 74 20 72 61 74 65 | 73 20 6f 66 20 73 70 65 |but rate|s of spe|
|00005c60| 63 69 66 69 63 20 6d 6f | 76 65 6d 65 6e 74 73 20 |cific mo|vements |
|00005c70| 77 65 72 65 20 63 6f 6e | 73 69 73 74 65 6e 74 0d |were con|sistent.|
|00005c80| 0a 66 6f 72 20 65 61 63 | 68 20 69 6e 64 69 76 69 |.for eac|h indivi|
|00005c90| 64 75 61 6c 2e 20 20 4e | 6f 20 74 65 6e 64 65 6e |dual. N|o tenden|
|00005ca0| 63 79 20 66 6f 72 20 68 | 69 67 68 20 6f 72 20 6c |cy for h|igh or l|
|00005cb0| 6f 77 20 72 61 74 65 73 | 20 6f 66 20 6f 76 65 72 |ow rates| of over|
|00005cc0| 61 6c 6c 20 6d 6f 74 6f | 72 0d 0a 61 63 74 69 76 |all moto|r..activ|
|00005cd0| 69 74 79 20 77 61 73 20 | 6e 6f 74 65 64 2e 0d 0a |ity was |noted...|
|00005ce0| 20 20 20 20 20 54 68 65 | 20 70 6f 73 74 75 72 61 | The| postura|
|00005cf0| 6c 20 61 6e 64 20 6d 6f | 74 6f 72 20 72 65 70 65 |l and mo|tor repe|
|00005d00| 72 74 6f 69 72 65 20 6f | 66 20 68 65 61 6c 74 68 |rtoire o|f health|
|00005d10| 79 20 66 75 6c 6c 2d 74 | 65 72 6d 20 6e 65 6f 6e |y full-t|erm neon|
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|00005d40| 65 73 65 20 64 61 74 61 | 20 63 61 6e 20 62 65 20 |ese data| can be |
|00005d50| 75 73 65 64 20 66 6f 72 | 20 63 6f 6d 70 61 72 69 |used for| compari|
|00005d60| 73 6f 6e 73 20 77 69 74 | 68 20 69 6e 66 61 6e 74 |sons wit|h infant|
|00005d70| 73 20 77 68 6f 0d 0a 68 | 61 76 65 20 6e 65 75 72 |s who..h|ave neur|
|00005d80| 6f 6c 6f 67 69 63 20 69 | 6d 70 61 69 72 6d 65 6e |ologic i|mpairmen|
|00005d90| 74 2c 20 62 75 74 20 63 | 6c 69 6e 69 63 61 6c 20 |t, but c|linical |
|00005da0| 61 70 70 6c 69 63 61 74 | 69 6f 6e 20 72 65 71 75 |applicat|ion requ|
|00005db0| 69 72 65 73 20 6c 61 72 | 67 65 72 20 73 61 6d 70 |ires lar|ger samp|
|00005dc0| 6c 65 73 0d 0a 61 6e 64 | 20 61 6e 61 6c 79 73 69 |les..and| analysi|
|00005dd0| 73 20 6f 66 20 74 68 65 | 20 71 75 61 6c 69 74 61 |s of the| qualita|
|00005de0| 74 69 76 65 20 61 73 70 | 65 63 74 73 20 6f 66 20 |tive asp|ects of |
|00005df0| 6d 6f 76 65 6d 65 6e 74 | 2e 0d 0a 0d 0a 50 6f 73 |movement|.....Pos|
|00005e00| 74 2d 43 6f 6d 6d 65 6e | 74 0d 0a 0d 0a 20 20 20 |t-Commen|t.... |
|00005e10| 20 20 44 72 2e 20 50 72 | 65 63 68 74 6c 20 61 64 | Dr. Pr|echtl ad|
|00005e20| 64 73 20 74 6f 20 68 69 | 73 20 61 6c 72 65 61 64 |ds to hi|s alread|
|00005e30| 79 20 69 6d 70 72 65 73 | 73 69 76 65 20 63 72 65 |y impres|sive cre|
|00005e40| 64 65 6e 74 69 61 6c 73 | 2e 20 20 48 65 20 68 61 |dentials|. He ha|
|00005e50| 73 20 70 69 6f 6e 65 65 | 72 65 64 0d 0a 6f 62 73 |s pionee|red..obs|
|00005e60| 65 72 76 61 74 69 6f 6e | 61 6c 20 73 74 75 64 69 |ervation|al studi|
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